Considerations for pharmacoepidemiology study design

Series: causal inference

Right now, an unorganized list of concepts I don’t want to forget about. Pharmacoepidemiology, general Rapid changes in the natural history of a disease or changes in treatment decisions will mean strong effects in relation to calendar time. Example: The management of COVID-19 improved throughout the pandemic independent of medication use. If you wanted to assess the comparative effectiveness of a drug, you would need to control for calendar time.